STAT4: Genetics, mechanisms, and implications for autoimmunity

Fibrogenesis: Mechanisms, Dynamics and Clinical Implications

Fibrosis is the pathological condition resulting in the growth of excess fibrous connective tissue in an organ or body system as a reparative or reactive process. In the field of clinical pathology, clinicians and medical scientists are endeavoring to translate experimental knowledge into effective, innovative treatments for a range of fibrotic conditions. The amelioration of whole organ functi...

Genetics of Autoimmunity

Positional cloning of genes underlying the heritability of autoimmune disease, as in many complex diseases, has largely been a frustrating exercise with few replicated positive ¢ndings despite enormous e¡orts at linkage and association mapping over the past ten years. Similar di⁄culties have been encountered by researchers attempting to identify such genes in murine models of autoimmunity. One ...

Unraveling the Genetics of Autoimmunity

The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases. These associations highlight key roles for lymphocyte activation and prioritize specific cytokine pathways and mechanisms of host-microbe recognition. Despite ...

Mercury-induced Autoimmunity: Genetics and Immunoregulation

T cell receptor genetics, autoimmunity and asthma.